Diabetes results also in changes in the profile of microRNAs detectable in blood and other body fluids. This has boosted an ever increasing interest in the use of circulating microRNAs as potential biomarkers to predict the development of diabetes and its devastating complications.
mitochondria and AGO-miRNA-containing processing. bodies, and the slight uncoupling of mitochondria leads to.Exosomal microRNA-29a mediates. cardiac dysfunction and mitochondrial inactivity in. obesity-related cardiomyopathy.
Keywords: pre-miRNA, microRNA, mitochondrial dysfunction, mitochondrial disease, biomarker, diagnostic, therapeutic target. 1. Introduction. To sustain life and to support organ functions, our body requires more than 90% of the energy, which is possible through mitochondria the...
Metabolic stress-induced mitochondrial dysfunction increases mitochondrial ROS generation and impairs oxidative phosphorylation resulting in cardiomyocyte hypertrophy and cell death. Impaired calcium (Ca2+) handling.
Mitochondrial dysfunction is implicated in various metabolic disorders, and its particularly noted for its role in the aging process. One critical way mitochondria contribute to aging is through the heightened production of ROS.
Proposed mechanisms of mitochondrial dysfunction in diabetic cardiomyopathy. Defects in the electron transport chain (ETC), increased monoamine oxidases (MAO) activity and decreased antioxidative capacity lead to increased reactive oxygen species/reactive nitrogen species...
Diagram of diabetes-associated cognitive dysfunction mechanisms, showing oxidative stress, mitochondrial dysfunction, neuroinflammation, ferroptosis, autophagy, microbiota-gut-brain axis and epigenetic regulation.
