Progressive FeLV infection carries the worst prognosis, and cats with progressive FeLV are at high risk of developing potentially fatal associated diseases. With a progressive infection, a cats bone marrow becomes infected with the virus and allows for continual viral replication.
Infection with FeLV can cause a variety of clinical signs, impacting a cat's longevity and quality of life. Vaccination and identification of infected cats is important in preventing disease transmission. The retrovirus status of every cat at risk of infection should be known.

Feline leukemia virus (FeLV) is one of the most common infectious causes of disease of cats globally. Infection with FeLV can cause a variety of clinical signs, impacting a cat's longevity and quality of life. Vaccination and identification of infected cats is important in preventing disease transmission. Etiology and Pathogenesis | Epidemiology and Transmission | Clinical Findings | Diagnosis ...

Studies show that 80% to 90% of FeLV-infected cats will die within three to four years of initial diagnosis. How is FeLV transmitted? FeLV is usually transmitted by direct contact between cats. The virus is fragile and cannot survive longer than a few hours outside the cat.
The average life expectancy for cats diagnosed with FeLV can vary significantly, but many FeLV-positive cats may live only a few years after diagnosis, with a substantial number suffering from related health issues.