Theres no specific antidote for a melatonin overdose, and treatment typically focuses on managing symptoms. In most cases, mild melatonin overdoses can be treated at home by stopping use and allowing the supplement to naturally clear from the body. Melatonin is a hormone that your body naturally makes. It comes in an OTC sleep aid. Its safe but could cause side effects if you take too much. Taking too much melatonin may cause dizziness, headaches, and more. Learn about dosages, symptoms, and safety tips for melatonin use. Treatment for Melatonin Overdose Melatonin overdose generally requires only supportive care and monitoring as it has low toxicity potential, with most patients recovering completely within 24-32 hours without specific interventions. Melatonin occurs naturally in the body and is involved in the natural regulation of sleep. Melatonin is sometimes used as a dietary supplement to help people sleep. Like other dietary supplements, there are few studies that have examined its effectiveness. Toxicity from melatonin appears to be mild. Melatonin can be a successful natural sleep aid. But a melatonin overdose can make it harder for you to fall asleep. Melatonin is a dietary supplement that has been used mainly by adults to help them fall asleep. Recently, there has been increased use among adults and children.1 Melatonin poisonings among children have also increased. Some of these poisoning have been serious, including hospitalizations.2

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