The expression of JHBPd2 was significantly higher in high-silk-yield varieties than in low-silk-yield varieties, and there was a positive correlation between its expression and silk yield.
The heat-tolerant cultivar maintained silk growth by activating more response pathways, displaying faster hormone responses, and up-regulating hormones. Taken together, we propose that hormones play an essential role in silk development and later fertilization process.
Here, we found that the application of a Juvenile hormone analog (JHA) extended the larval period of Bombyx mori and increased the weight and thickness of the cocoon.

The steroid hormone 20-hydroxyecdysone (20E), which is known to regulate insect molting and metamorphosis, is crucial for the normal development of silk glands (SGs) in the silkworm Bombyx mori.
Here the authors use single-cell RNA sequencing to build an atlas of the silkworm silk gland and reveal the heterogeneity of silk gland cells.

Juvenile hormone and its analogues are found to cause various biochemical changes in the larval tissues. It also increases larval body weight, coccon weight and silk shell weight which is the result of secretion of more silk protein and lengthening of last instar.