The purposes of this study were to determine whether acetaminophen (Acet), a weak PG-synthesis inhibitor, influences kidney function in the renal PG-dependent state of anesthesia and sodium depletion. Comparisons were made with ibuprofen (Ibu). Measurements of PGE2 excretion were used to assess renal PG synthesis. Acet (15 mg/kg) and Ibu (10 mg/kg) both decreased renal blood flow and glomerular filtration rate by approximately 20-30% in normal, anesthetized, sodium-replete dogs.
- Serum creatinine can be used as a rough benchmark of glomerular filtration rate (GFR). For example, if serum creatinine is 3 mg/dL in a dog with CKD (reference range, about 1 mg/dL), NSAID administration can be decreased from once a day to once every 3 days. This administration interval provides more time for the kidneys to clear the drug.
- Is heart disease or kidney disease causing the clinical signs? Prioritize the disease causing the most severe clinical signs. Are both biochemistry analysis and thoracic radiography needed? Usually yes, because the information they provide is often complementary. For example, when azotemia is present, radiographs will help indicate concurrent presence of active CHF (eg, pulmonary venous congestion, pulmonary edema, pleural effusion) and therefore will help guide decisions about diuretic dose reductions.
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